Univ.Prof. Dr. Jürgen Sandkühler

Head of Department
Department(s): Department of Neurophysiology (Center for Brain Research)
Position: Professor
Location: Spitalgasse 4
Telephone: 40160-34101
E-Mail:
Download Curriculum vitae (CV)

Research Area:
Pain

Research Interests:
Analgesics, Opioid, Astrocytes, Behavior, Animal, Cytokines, GABAergic Neurons, Inflammation, Long-Term Potentiation, Microglia, Nociception, Optogenetics, Patch-Clamp Techniques, Spinal Cord, Synapses

Principle Investigator(s):

• Sandkühler, Jürgen (Head)

Interest Group(s):

• Pain Interest Group (Head)
• Neuroinflammation / Inflammatory Diseases of the Nervous System / Multiple Sclerosis

Grant(s):

• Cell communication in health and disease, sub-project: Glial-neuron interactions in synaptic plasticity (Responsible)
• Synaptic long-term potentiation after opioid withdrawal (Responsible)
• Synaptic mechanisms of pain amplification and pain generation in the spinal cord (Responsible)

Abstract:

Parts of the nervous system are dedicated to transmit and process pain-related information in order to protect the body from potentially harmful stimuli. Virtually all state-of-the-art technologies of modern life sciences are presently employed in pain research. Nociceptive afferents can be stimulated selectively and nociceptive output parameters can be assessed quantitatively with high precision. By virtue of its nature, pain research creates an interdisciplinary link between neurobiologists, psychologists, physiologists and pain therapists, to name but a few examples.

Selected Publications:

1. Kronschläger MT, Drdla-Schutting R, Gassner M, Honsek SD, Teuchmann HL, Sandkühler J (2016) Gliogenic LTP spreads widely in nociceptive pathways Science, 354: 1144-1148
   | Article (PDF): 1 2 |
2. Xanthos D,Sandkühler J (2014) Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity Nat. Rev. Neurosci., 15: 43-53
   | Article (PDF) || Weblink |
3. Drdla R, Benrath J, Wunderbaldinger G, Sandkühler J (2012) Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration Science, 335: 235-238
   | Article (PDF) || Weblink |
4. Drdla R., Gassner M., Gingl E., Sandkühler J. (2009) Induction of synaptic long-term potentiation after opioid withdrawal Science, 325: 207-210
   | Article (PDF) || Supplement |
5. Ikeda H., Stark J., Fischer H., Wagner M., Drdla R., Jäger T., Sandkühler J. (2006) Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science, 312: 1659-1662
   | Article (PDF) |

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