Ao.Prof. Dr. Sigismund Huck, em.

Department(s): Division of Pathobiology of the Nervous System (Center for Brain Research)
Position: Associate Professor
Birthday: 21st September
Location: Spitalgasse 4
Telephone: 40160-34090
E-Mail:
Download Curriculum vitae (CV)

Research Area:
Autonomic Nervous System, Receptors, Neurotransmitter, Receptors, Nicotinic

Research Interests:
Neuropharmacology, Neurophysiology

Principle Investigator(s):

• Scholze, Petra

Grant(s):

• OCT3 im sympathischen Nervensystem der Ratte (Responsible)
• Secretagogue nicotinic acetylcholine receptor channels in the sympathetic nervous system: function, pharmacology, and regulation (Responsible)
• Human Nicotinic Receptor Polymorphisms in Synaptic Pathology
• Neuronal nicotinic acetylcholine receptors dissected

Cellular and Molecular Neurobiology

Abstract:

My prime interest are the properties and function of nAChRs in both the CNS and the PNS

Techniques:

Transmitter release; Patch Clamp Electrophysiology; Cell and Tissue Culture; Ca Imaging

Selected Publications:

1. Beiranvand F, Zlabinger C, Orr-Urtreger A, Ristl R, Huck S, Scholze P (2014) Nicotinic acetylcholine receptors control acetylcholine and noradrenaline release in the rodent habenulo-interpeduncular complex Br J Pharmacol, 171 (23): 5209-5224
   | Article (PDF) |
2. Ciuraszkiewicz A, Schreibmayer W, Platzer D, Orr-Urtreger A, Scholze P, Huck S. (2013) Single-channel properties of α3β4, α3β4α5, and α3β4β2 nicotinic ACh receptors in mice lacking specific nAChR subunits J Physiol, 591: 3271-3288
   | Article (PDF) |
3. Scholze P, Koth G, Orr-Urtreger A, Huck S (2012) Subunit composition of α5-containing nicotinic receptors in the rodent habenula J Neurochem, 121(4): 551-560
   | Article (PDF) |
4. David R, Ciuraszkiewicz A, Simeone X, Orr-Urtreger A, Papke RL, McIntosh JM, Huck S, Scholze P (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes Eur J Neurosci, 6: 978-993
   | Article (PDF): 1 2 |
5. Fischer H., Orr-Urtreger A., Role L.W., Huck S (2005) Selective deletion of the alpha 5 subunit differentially affects somatio-dendritic versus axonally targeted nicotinic ACh receptors in mouse J Physiol, 563: 119-137

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