DI Mag. Christoph Wiesinger, PhD

Department(s): Department of Pathobiology of the Nervous System (Center for Brain Research)
Position: Research Assistant
Birthday: 1st January
Location: Spitalgasse 4
Telephone: 40160-34303
E-Mail:

Research Area:
Peroxisomes in Brain Disorders

Research Interests:
Adrenoleukodystrophy, ATP-Binding Cassette Transporters, Lipid Metabolism Disorders

Principle Investigator(s):

• Berger, Johannes

Interest Group(s):

• X-linked Adrenoleukodystrophy

Grant(s):

• The peroxisomal ABC transporter ABCD3: substrate specificity and metabolic interplay between peroxisomes and the ER (Responsible)
• Immunzellen bei X-chromosomaler Adrenoleukodystrophie
• Therapeutic challenge in Leukodystrophies: Translation and ethical research towards clinical trials acronym "Leuko Treat"
• Übernahme der Reise- u. Übernachtungskosten für AMN Patienten aus Deutschland zur Teilnahme an einer klinischen Studie

Selected Publications:

1. Kunze M, Malkani N, Maurer-Stroh S, Wiesinger C, Schmid J, Berger J (2015) Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import: The Co-receptor PEX5L drastically increases the Interaction Strength between the Cargo Protein and the Receptor PEX7 J Biol Chem, 290: 4928-4940
   | Article (PDF) |
2. Wiesinger C, Eichler F, Berger J, (2015) The genetic landscape of X-linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis Appl Clin Genet, 8: 109
   | Article (PDF) |
3. Weber F, Wiesinger Ch, Forss-Petter S, Regelsberger G, Einwich A, Weber W, Köhler W, Stockinger H, Berger J, (2014) X-linked adrenoleukodystrophy: Very long-chain fatty acid metabolism is severely impaired in monocytes but not in lymphocytes Hum Mol Genet, 23 (10): 2542-2550
   | Article (PDF) |
4. Muneer Z, Wiesinger C, Voigtländer T, Werner H, Berger J, Forss-Petter S (2014) Abcd2 Is a Strong Modifier of the Metabolic Impairments in Peritoneal Macrophages of Abcd1-Deficient Mice PLoS One, 9 (9): e108655
   | Article (PDF) |
5. Wiesinger C, Kunze M, Regelsberger G, Forss-Petter S, Berger J. (2013) Impaired Very Long-Chain Acyl-CoA β-Oxidation in Human X-ALD Fibroblasts Is a Direct Consequence of ABCD1 Transporter Dysfunction J Biol Chem, 288: 19269-19279

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