Sandkühler, Jürgen

Department: Department of Neurophysiology
Head: Sandkühler, Jürgen, Univ.Prof. Dr.

Research Area:
Pain research, neurobiology of pain amplification and pain therapy

Description:

Parts of the nervous system are dedicated to transmit and process pain-related information in order to protect the body from potentially harmful stimuli. This nociceptive system is a powerful model system for studying the properties of the nervous system in health and disease from the molecular to the systemic and the behavioral levels.

Virtually all state-of-the-art technologies of modern life sciences are presently employed in pain research. It is an advantageous feature of the complex nociceptive system that it has well-defined input and output pathways. This makes it much easier to study.

Nociceptive afferents can be stimulated selectively and nociceptive output parameters can be assessed quantitatively with high precision. By virtue of its nature, pain research creates an interdisciplinary link between neurobiologists, psychologists, physiologists and pain therapists, to name but a few examples. Since pain is a major personal, medical and social burden, justification of practice has never been a problem for pain research.

Members:

Ada, Sibel, MSc
Drdla-Schutting, Ruth, Assoc. Prof., PhD
Drescher, Ilonka
Haider, Teresa, MSc
Heinke, Bernhard, Priv.Doz. Dr.med.vet.
Hogri, Roni, Dr.
Holzinger, Raphael, Ing.
Janeselli, Gilbert
Klinger, Laura, MSc
Kronschläger, Mira, PhD
Kurija, Danijela
Mussetto, Valeria, MD
Siegert, Anna, MSc
Teuchmann, Hannah, MSc.
Tilscher, Alexandra
Trofimova, Lidia, MSc

Selected Publications of Principle Investigator:

1. Kronschläger MT, Drdla-Schutting R, Gassner M, Honsek SD, Teuchmann HL, Sandkühler J (2016) Gliogenic LTP spreads widely in nociceptive pathways Science, 354: 1144-1148
   | Article (PDF): 1 2 |
2. Xanthos D,Sandkühler J (2014) Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity Nat. Rev. Neurosci., 15: 43-53
   | Article (PDF) || Weblink |
3. Drdla R, Benrath J, Wunderbaldinger G, Sandkühler J (2012) Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration Science, 335: 235-238
   | Article (PDF) || Weblink |
4. Drdla R., Gassner M., Gingl E., Sandkühler J. (2009) Induction of synaptic long-term potentiation after opioid withdrawal Science, 325: 207-210
   | Article (PDF) || Supplement |
5. Ikeda H., Stark J., Fischer H., Wagner M., Drdla R., Jäger T., Sandkühler J. (2006) Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science, 312: 1659-1662
   | Article (PDF) |