Medical NeuroScience Cluster Publications by
Höftberger Romana, Assoc.Prof.Priv.-Doz.Dr. :

2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004

2021 Original Articles

• Zrzavy T, Schwaiger C, Wimmer I, Berger T, Bauer J, Butovsky O, Schwab J, Lassmann H, Höftberger R (2021) Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury Brain, 144(1): 144-161
• Beltrán E+, Paunovic M+, Gebert D, Cesur E, Jeitler M, Höftberger R, Malotka J, Mader S, Kawakami N, Meinl E, Bradl M*, Dornmair K*, Lassmann H* + sharing co-first; *sharing senior authorship (2021) Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis Acta Neuropathol, 141(1): 67-83

2020 Original Articles

• Höftberger R, Guo Y, Flanagan E, Lopez-Chiriboga A, Endmayr V, Hochmeister S, Joldic D, Pittock S, Tillema J, Gorman M, Lassmann H, Lucchinetti C (2020) The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody Acta Neuropathol, 139(5): 875-892

2020 Book Chapters

• Höftberger R, Lassmann H (2020) Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalomyelitis. In: Fabrice Chretien, Infections of the Central Nervous System: Pathology and Genetics John Wiley & Sons, Inc; Oxford, UK, Hoboken, USA: 251-257

2019 Original Articles

• Gross C, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher A, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud D, Loussouarn D, Parratt J, Barnett M, Buckland M, Hardy T, Reddel S, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth S, Martin-Blondel G, Wiendl H, Liblau R (2019) CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome Nat Commun, 10 (1): 5779
• Kau T, Hametner S, Endmayr V, Deistung A, Prihoda M, Haimburger E, Menard C, Haider T, Höftberger R, Robinson S, Reichenbach J, Lassmann H, Traxler H, Trattnig S, Grabner G (2019) Microvessels may Confound the “Swallow Tail Sign” in Normal Aged Midbrains: A Postmortem 7 T SW-MRI Study J Neuroimaging, 29(1): 65-69
• Zrzavy T, Höftberger R, Berger T, Rauschka H, Butovsky O, Weiner H, Lassmann H (2019) Pro-inflammatory Activation of Microglia in the Brain of Patients with Sepsis Neuropathol Appl Neurobiol, 45(3): 278-290

2018 Original Articles

• Ricken G, Schwaiger C, De Simoni D, Pichler V, Lang J, Glatter S, Macher S, Rommer P, Scholze P, Kubista H, Koneczny I, Höftberger R (2018) Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis Front Neurol, 9: 841
• Spadaro M, Winklmeier S, Beltrán E, Macrini C, Höftberger R, Schuh E, Thaler F, Gerdes L, Laurent S, Gerhards R, Brändle S, Dornmair K, Breithaupt C, Krumbholz M, Moser M, Kirshnamoorthy G, Kamp F, Jenne D, Hohlfeld R, Kümpfel T, Lassmann H, Kawakami N, Meinl E (2018) Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein Ann Neurol, 84(2): 315-328
• Hametner S, Endmayr V, Deistung A, Palmrich P, Prihoda M, Haimburger E, Menard C, Feng X, Haider T, Leisser M, Köck U, Kaider A, Höftberger R, Robinson S, Reichenbach JR, Lassmann H, Traxler H, Trattnig S, Grabner G. (2018) The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation - A biochemical and histological validation study Neuroimage, 179: 117-133.
• Weinhofer I, Zierfuss B, Hametner S, Wagner M, Popitsch N, Machacek C, Bartolini B, Zlabinger G, Ohradanova-Repic A, Stockinger H, Köhler W, Höftberger R, Regelsberger G, Forss-Petter S, Lassmann H, Berger J (2018) Impaired plasticity of macrophages in X-linked adrenoleukodystrophy Brain, 141: 2329-2342
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• Blaabjerg M, Hemdrup A, Drici L, Ruprecht K, Garred P, Höftberger R, Kristensen B, Kondziella D, Sejbaek T, Hansen S, Nielsen H, Jensen P, Meyer M, Paul F, Lassmann H, Larsen M, Illes Z (2018) Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) Front Immunol, 9: 741

2017 Original Articles

• Wiggermann V, Hametner S, Hernández-Torres E, Kames C, Endmayr V, Kasprian G, Höftberger R, Li D, Traboulsee A, Rauscher A (2017) Susceptibility-sensitive MRI of multiple sclerosis lesions and the impact of normal-appearing white matter changes NMR Biomed, 30 (8): e3727
• Dal-Bianco A, Grabner G, Kronnerwetter C, Weber M, Höftberger R, Berger T, Auff E, Leutmezer F, Trattnig S, Lassmann H, Bagnato F, Hametner S (2017) Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging Acta Neuropathol, 133 (1): 25-42
• Peschl P, Schanda K, Zeka B, Given K, Böhm D, Ruprecht K, Saiz A, Lutterotti A, Rostásy K, Höftberger R, Berger T, Macklin W, Lassmann H, Bradl M, Bennett J, Reindl M (2017) Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination J Neuroinflammation, 14 (1): 208
• Körtvélyessy P, Breu M, Pawlitzki M, Metz I, Heinze H, Matzke M, Mawrin C, Rommer P, Kovacs G, Mitter C, Reindl M, Brück W, Wandinger K, Lassmann H, Höftberger R, Leypoldt F (2017) ADEM-like presentation, anti-MOG antibodies, and MS pathology: TWO case reports Neurol Neuroimmunol Neuroinfl, 4 (3): e335

2017 Reviews

• Peschl P, Bradl M, Höftberger R, Berger T, Reindl M (2017) Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases Front Immunol, 8: 529

2017 Book Chapters

• Höftberger R, Lassmann H (2017) Immune-mediated disorders. In: , Handbook of Clinical Neurology : 285-299
• Höftberger R, Lassmann H (2017) Inflammatory demyelinating diseases of the central nervous system. In: , Handbook of Clinical Neurology : 263-283

2016 Original Articles

• Tuller F, Holzer H, Schanda K, Aboulenein-Djamshidian F, Höftberger R, Khalil M, Seifert-Held T, Leutmezer F, Berger T, Reindl M (2016) Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders J Neuroinflammation, 13 (1)
• Grisold A, Brandl I, Lindeck-Pozza E, Pöhnl R, Pratschner T, Schmaldienst S, Höftberger R, Grisold W (2016) Transient paralysis of diaphragm in Waldenstroms disease; a focal variant of Guillain-Barré syndrome? J Neurol Sci, 366: 1-2
• Baumann M, Hennes E, Schanda K, Karenfort M, Kornek B, Seidl R, Diepold K, Lauffer H, Marquardt I, Strautmanis J, Syrbe S, Vieker S, Höftberger R, Reindl M, Rostásy K (2016) Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases Mult Scler, 22 (14): 1821-1829
• Gelpi E, Höftberger R, Graus F, Ling H, Holton J, Dawson T, Popovic M, Pretnar-Oblak J, Högl B, Schmutzhard E, Poewe W, Ricken G, Santamaria J, Dalmau J, Budka H, Revesz T, Kovacs G (2016) Neuropathological criteria of anti-IgLON5-related tauopathy Acta Neuropathol, 132 (4): 531-543
• Kovacs G, Rahimi J, Ströbel T, Lutz M, Regelsberger G, Streichenberger N, Perret-Liaudet A, Höftberger R, Liberski P, Budka H, Sikorska B (2016) Tau Pathology in Creutzfeldt-Jakob Disease Revisited Brain Pathol,
• Haider L, Zrzavy T, Hametner S, Höftberger R, Bagnato F, Grabner G, Trattnig S, Pfeifenbring S, Brück W, Lassmann H (2016) The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain Brain, 139 (3): 807-815

2015 Original Articles

• Hoftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer M, Graus F, Dalmau J (2015) Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients Neurology, 84 (24): 2403-2412
• Aboulenein-Djamshidian F, Höftberger R, Waters P, Krampla W, Lassmann H, Budka H, Vincent A, Kristoferitsch W (2015) Reduction in Serum Aquaporin-4 Antibody Titers During Development of a Tumor-Like Brain Lesion in a Patient With Neuromyelitis Optica: A Serum Antibody–Consuming Effect? J Neuropath Exp Neurol, 74 (3): 194-197
• Sieczkowski E, Milenkovic I, Venkataramani V, Giera R, Ströbel T, Höftberger R, Liberski PP, Auff E, Wirths O, Bayer TA, Kovacs GG. (2015) I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies. J Alzheimers Dis, 44: 103-114
• Kovacs GG, van der Zee J, Hort J, Kristoferitsch W, Leitha T, Höftberger R, Ströbel T, Van Broeckhoven C, Matej R (2015) Clinicopathological description of two cases withSQSTM1gene mutation associated with frontotemporal dementia Neuropathology, 36 (1): 27-38
• Leypoldt F, Höftberger R, Titulaer M, Armangue T, Gresa-Arribas N, Jahn H, Rostásy K, Schlumberger W, Meyer T, Wandinger K, Rosenfeld M, Graus F, Dalmau J (2015) Investigations on CXCL13 in Anti– N -Methyl- D -Aspartate Receptor Encephalitis Jama Neurol, 72 (2): 180
• Ariño H, Höftberger R, Gresa-Arribas N, Martínez-Hernández E, Armangue T, Kruer M, Arpa J, Domingo J, Rojc B, Bataller L, Saiz A, Dalmau J, Graus F (2015) Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies Jama Neurol, 72 (8): 874
• Höftberger R, Rosenfeld M, Dalmau J (2015) Update on neurological paraneoplastic syndromes Curr Opin Oncol, 27 (6): 489-495
• Höftberger R, Leisser M, Bauer J, Lassmann H (2015) Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ? Acta Neuropathologica Communications, 3 (1): 80
• Di Pauli F, Hoftberger R, Reindl M, Beer R, Rhomberg P, Schanda K, Sato D, Fujihara K, Lassmann H, Schmutzhard E, Berger T (2015) Fulminant demyelinating encephalomyelitis: Insights from antibody studies and neuropathology Neurol Neuroimmunol Neuroinflamm, 2 (6): e175-e175

2015 Reviews

• Höftberger R (2015) Neuroimmunology: An Expanding Frontier in Autoimmunity Front Immunol, 6

2014 Original Articles

• Kruer M, Hoeftberger R, Lim K, Coryell J, Svoboda M, Woltjer R, Dalmau J (2014) Aggressive Course in Encephalitis With Opsoclonus, Ataxia, Chorea, and Seizures JAMA Neurol, 71 (5): 620
• Titulaer M, Höftberger R, Iizuka T, Leypoldt F, McCracken L, Cellucci T, Benson L, Shu H, Irioka T, Hirano M, Singh G, Cobo Calvo A, Kaida K, Morales P, Wirtz P, Yamamoto T, Reindl M, Rosenfeld M, Graus F, Saiz A, Dalmau J (2014) Overlapping demyelinating syndromes and anti-N-methyl-D-aspartate receptor encephalitis Ann Neurol, 75 (3): 411-428
• Höftberger R, Sabater L, Velasco F, Ciordia R, Dalmau J, Graus F (2014) Carbonic anhydrase-related protein VIII antibodies and paraneoplastic cerebellar degeneration Neuropathol Appl Neurobiol, 40 (5): 650-653
• Armangue T, Leypoldt F, Málaga I, Raspall-Chaure M, Marti I, Nichter C, Pugh J, Vicente-Rasoamalala M, Lafuente-Hidalgo M, Macaya A, Ke M, Titulaer M, Höftberger R, Sheriff H, Glaser C, Dalmau J (2014) Herpes simplex virus encephalitis is a trigger of brain autoimmunity Ann Neurol, 75 (2): 317-323

2013 Original Articles

• Kovacs G, Milenkovic I, Wöhrer A, Höftberger R, Gelpi E, Haberler C, Hönigschnabl S, Reiner-Concin A, Heinzl H, Jungwirth S, Krampla W, Fischer P, Budka H (2013) Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series Acta Neuropathol, 126 (3): 365-384
• Kovacs G, Peden A, Weis S, Höftberger R, Berghoff A, Yull H, Ströbel T, Koppi S, Katzenschlager R, Langenscheidt D, Assar H, Zaruba E, Gröner A, Voigtländer T, Puska G, Hametner E, Grams A, Muigg A, Knoflach M, László L, Ironside J, Head M, Budka H (2013) Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity? Acta Neuropathologica Communications, 1 (1): 72
• Sabater L, Höftberger R, Boronat A, Saiz A, Dalmau J, Graus F (2013) Antibody Repertoire in Paraneoplastic Cerebellar Degeneration and Small Cell Lung Cancer PLoS One, 8 (3): e60438
• Höftberger R, Sabater L, Ortega A, Dalmau J, Graus F (2013) Patient With Homer-3 Antibodies and Cerebellitis JAMA Neurol, 70 (4): 506
• Höftberger R, Kovacs G, Sabater L, Nagy P, Racz G, Miquel R, Dalmau J, Graus F (2013) Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration J Neuroimmunol, 256 (1-2): 91-93
• Fischer MT, Wimmer I, Höftberger R, Gerlach S, Haider L, Zrzavy T, Hametner S, Mahad D, Binder CJ, Krumbholz M, Bauer J, Bradl M, Lassmann H. (2013) Disease-specific molecular events in cortical multiple sclerosis lesions Brain, 136(Pt 6): 1799-1815
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• Misu T, Höftberger R, Fujihara K, Wimmer I, Takai Y, Nishiyama S, Nakashima I, Konno H, Bradl M, Garzuly F, Itoyama Y, Aoki M, Lassmann H (2013) Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica Acta Neuropathol, 125(6): 815-827
• Berghoff AS, Lassmann H, Preusser M, Höftberger R. (2013) Characterization of the inflammatory response to solid cancer metastases in the human brain Clin Exp Metastasis, 30(1): 69-81

2013 Reviews

• Höftberger R, Armangue T, Leypoldt F, Graus F, Dalmau J (2013) Clinical Neuropathology practice guide 4-2013: post-herpes simplex encephalitis: N-methyl-Daspartate receptor antibodies are part of the problem Clin Neuropathol, 32 (07): 251-254

2012 Original Articles

• Alafuzoff I, Gelpi E, Al-Sarraj S, Arzberger T, Attems J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Englund E, Ferrer I, Gentleman S, Giaccone G, Graeber M, Hortobagyi T, Höftberger R, Ironside J, Jellinger K, Kavantzas N, King A, Korkolopoulou P, Kovács G, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal D, Wharton S, Kretzschmar H (2012) The need to unify neuropathological assessments of vascular alterations in the ageing brain Exp Gerontol, 47 (11): 825-833

2011 Original Articles

• Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, Lassmann H. (2011) Oxidative damage in multiple sclerosis lesions Brain, 134(Pt 7):: 1914-1924
• Kou J, Kovacs GG, Höftberger R, Kulik W, Brodde A, Forss-Petter S, Hönigschnabl S, Gleiss A, Brügger B, Wanders R, Just W, Budka H, Jungwirth S, Fischer P, Berger J. (2011) Peroxisomal alterations in Alzheimer's disease Acta Neuropathol, 122: 271-283
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2010 Original Articles

• Aboul-Enein F, Krššák M, Höftberger R, Prayer D, Kristoferitsch W (2010) Reduced NAA-Levels in the NAWM of Patients with MS Is a Feature of Progression. A Study with Quantitative Magnetic Resonance Spectroscopy at 3 Tesla PLoS One, 5 (7): e11625
• Höftberger R, Fink S, Aboul-Enein F, Botond G, Olah J, Berki T, Ovadi J, Lassmann H, Budka H, Kovacs GG. (2010) Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis Glia, 58(15):1847-1857
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• Höftberger R*/Kunze M* (*joint authorship), Voigtländer T, Unterberger U, Regelsberger G, Bauer J, Aboul-Enein F, Garzuly F, Forss-Petter S, Bernheimer H, Berger J, Budka H (2010) Peroxisomal localization of the proopiomelanocortin-derived peptides ß-Lipotropin and ß-Endorphin Endocrinology, 151: 4801-4810
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2008 Original Articles

• Aboul-Enein F, Höftberger R, Buxhofer-Ausch V, Drlicek M, Lassmann H, Budka H, Kristoferitsch W. (2008) Neocortical neurones may be targeted by immune attack in anti-Yo paraneoplastic syndrome Neuropathol Appl Neurobiol, 34(2): 248-252
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2007 Original Articles

• Höftberger R, Garzuly F, Dienes HP, Grubits J, Rohonyi B, Fischer G, Hanzely Z, Lassmann H, Budka H (2007) Fulminant central nervous system demyelination associated with interferon-{alpha} therapy and hepatitis C virus infection Mult Scler, 13(9): 1100-1106
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2006 Original Articles

• Kaushansky N, Zhong MC, Kerlero de Rosbo N, Hoeftberger R, Lassmann H, Ben-Nun A (2006) Epitope specificity of autoreactive T and B cells associated with experimental autoimmune encephalomyelitis and optic neuritis induced by oligodendrocyte-specific protein in SJL/J mice J Immunol, 15;177(10): 7364-7376
• Aboul-Enein F., Weiser, P., Höftberger, R., Lassmann, H., and Bradl, M. (2006) Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis Acta Neuropathol, 111: 539-547

2005 Original Articles

• Kovacs,-G-G; Hoftberger,-R; Majtenyi,-K; Horvath,-R; Barsi,-P; Komoly,-S; Lassmann,-H; Budka,-H; Jakab,-G (2005) Neuropathology of white matter disease in Leber's hereditary optic neuropathy Brain, 128(Pt. 1): 35-41

2004 Original Articles

• Hoftberger,-R; Aboul-Enein,-F; Brueck,-W; Lucchinetti,-C; Rodriguez,-M; Schmidbauer,-M; Jellinger,-K; Lassmann,-H (2004) Expression of major histocompatibility complex class I molecules on the different cell types in multiple sclerosis lesions Brain Pathol, 14(1): 43-50
• de-Rosbo,-N-K; Kaye,-J-F; Eisenstein,-M; Mendel,-I; Hoeftberger,-R; Lassmann,-H; Milo,-R; Ben-Nun,-A (2004) The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-as J Immunol, 172(2): 1426-1435
• Pellkofer,-H; Schubart,-A-S; Hoftberger,-R; Schutze,-N; Pagany,-M; Schuller,-M; Lassmann,-H; Hohlfeld,-R; Voltz,-R; Linington,-C (2004) Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat Brain, 127 (Pt. 8): 1822-1830