Ao.Univ.Prof. Dr. Jan Bauer

Department(s): Department of Neuroimmunology (Center for Brain Research)
Position: Associate Professor
Location: Spitalgasse 4
Telephone: 40160-34213
E-Mail:

Research Area:
Autoimmune Diseases of the Nervous System

Research Interests:
Antibody-Dependent Cell Cytotoxicity, Autoimmune Diseases of the Nervous System, Cytotoxicity, Immunologic, Encephalitis Viruses, Epilepsy, Multiple Sclerosis

Principle Investigator(s):

• Bauer, Jan (Head)
• Bauer, Jan

Interest Group(s):

• Epilepsy
• Neuroinflammation / Inflammatory Diseases of the Nervous System / Multiple Sclerosis

Grant(s):

• Grant for Multiple Sclerosis Innovation 2020 Research Project (Responsible)
• Inflammation and Viruses in Epilepsy (Responsible)
• Rasmussen Encephalitis: cause and immune reactions (Responsible)
• Treatment of MOG peptide-induced EAE in marmosets (Responsible)

Abstract:

My research focuses on mechanisms of inflammatory diseases of the CNS. In this large area my special interests are the inflammatory reactions in epileptic disorders. The study of Rasmussen encephalitis, antibody-associated encephalitides and other forms of epilepsy are performed in close cooperation with Prof. Dr. Christian Bien in Bielefeld, Germany. This work is complemented by the study of other diseases such as Multiple Sclerosis and various viral encephalitides. Besides the analysis of human brain we also study animal models of autoimmune or virus induced inflammatory CNS disease which may give new insights in the development of CNS inflammation.

Selected Publications:

1. Gross C, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher A, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud D, Loussouarn D, Parratt J, Barnett M, Buckland M, Hardy T, Reddel S, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth S, Martin-Blondel G, Wiendl H, Liblau R (2019) CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome Nat Commun, 10 (1): 5779
2. Tröscher A, Wimmer I, Quemada-Garrido L, Köck U, Gessl D, Verberk S, Martin B, Lassmann H, Bien C, Bauer J (2019) Microglial nodules provide the environment for pathogenic T cells in human encephalitis Acta Neuropathol, 137(4): 137(4):619-635
3. Wimmer I, Tröscher A, Brunner F, Rubino S, Bien C, Weiner H, Lassmann H, Bauer J (2018) Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples Sci Rep, 8 (1): 6351
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4. Laukoter S, Rauschka H, Tröscher A, Köck U, Saji E, Jellinger K, Lassmann H, Bauer J (2017) Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis Acta Neuropathol, 133(4): 613-627
5. Bauer J, Gold R, Adams O, Lassmann H. (2015) Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome (IRIS) Acta Neuropathol, 130(6): 751-764

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