Neuronal mechanism involved in the learning of maternal behaviour discovered

In the course of their preclinical investigation, the scientists led by Daniela Pollak from the Division of Neurophysiology and Neuropharmacology at MedUni Vienna's Center for Physiology and Pharmacology analysed maternal behaviour of female mice towards newborn pups. While the neural processes involved in the development of maternal care behaviour in female mice after birth have already been described, the current study addressed the question which circuits in the brain are activated during the learning of care behaviour in nulliparous virgin females, female mice that have not been pregnant.

The researchers found the answer in the anterior cingulate cortex (ACC), a region in the prefrontal lobe of the brain that is associated, among other things, with the recognition and evaluation of social processes and the development of emotional awareness. The mouse model showed that in females who have not been pregnant or given birth, the ACC gets activated when they acquire maternal behaviour upon first contact with pups. "Our observations have demonstrated that, through repeated experience with pups, the virgin females are capable of learning maternal behaviour that fully resembles those of mothers after delivery," explains project leader Daniela Pollak, reporting from her research. The study revealed that during this learning process ACC activity is controlled by an excitatory feedback circuit involving a specific group of neurons in a central brain region (the thalamus).

Learning through repeated experience
Maternal behaviour is defined, among other things, by sensitivity and responsiveness to signals of infant needs. It is instinctively displayed in virtually all mammals and upon first contact with newborns immediately after delivery. In some species, such as rodents, even animals that have never given birth may exhibit maternal care behaviour toward newborns. In this case, the care behaviour, such as returning displaced pups from outside the nest back into the nest area, where they are warm and protected from predators, are acquired through repeated experience with the pups.

We know, for example from observations in adoptive parents, that humans can also learn parental behaviours. Various pathological conditions, such as postpartum depression or postpartum psychosis can lead to alterations in maternal behaviour and disrupt the mother-child bonding process. "By showing that maternal behaviours can be acquired and identifying the underlying neuronal circuits in the brain that control this acquisition, we are creating a potential basis for developing therapeutic options for these clinical situations," says Daniela Pollak, outlining the translational relevance of the study results, which were obtained in collaboration with Tibor Harkany from the Division of Molecular Neurosciences at MedUni Vienna's Center for Brain Research.

Publication: The EMBO Journal An accessory prefrontal cortex-thalamic circuit sculpts maternal behavior in virgin female mice Micaela Glat, Anna Gundacker, Laura Cuenca Ric, Barbara Czuczu, Yoav Ben Simon, Tibor Harkany and Daniela D. Pollak Doi: 10.15252/embj.2022111648