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Pioneering MRI imaging method captures brain glucose metabolism without the need for administration of radioactive substances

Metabolic disorders play a central role in many common conditions, including Alzheimer's,..

How evolution has influenced the shape of the brain - MedUni Vienna is conducting research into the connections between brain structure and function in humans and animals

The connections between the structure of the brain and its function are a key focus of..

Gregor Kasprian takes over the professorship for neuroradiology - Expert from MedUni Vienna with a focus on fetal and pediatric neuroradiology

Gregor Kasprian took over the professorship for neuroradiology (§98) at MedUni Vienna in mid-April..

Sarah Melzer appointed as new member of the Junge Akademie - The Austrian Academy of Sciences (ÖAW) has welcomed new researchers into its ranks

At the annual election session of the Austrian Academy of Sciences (ÖAW), Sarah Melzer from MedUni..

Silk confirmed as a promising material for repair of injured nerves

The treatment of nerve injuries with the aid of nerve guidance conduits has led to the desired..

Researcher of the Month - April 2023 - Roman ROMANOV

Ap. Prof. Dr. Roman ROMANOV, PhD

Vienna as the international research centre for ultrasound brain therapies

In recent years, ultrasound brain therapies have gained importance worldwide and are considered a..

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Researcher of the Month - April 2023 - Roman ROMANOV

Ap. Prof. Dr. Roman ROMANOV, PhD

MedUni Wien RESEARCHER OF THE MONTH April 2023

Dopamine in the hypothalamus is best known for inhibiting prolactin release from the pituitary when released into the hypophyseal portal system on a daily basis. The team of researchers led by Dr. Harkany and Dr. Romanov showed that this previously dominant concept is not complete. Researchers focused on the specific cell fraction of hypothalamic dopamine cells located in the area close to the brain ventricle system (so-called periventricular area) and identified that these neurons are controlled by the brain's "clock center" suggesting a putative position in the circadian pacemaker circuit. In turn, the investigated neurons release dopamine in the lateral septum, an area of the brain that regulates autonomic processes and controls locomotion. Since many psychostimulants act on the dopamine system, Romanov and colleagues tested whether one of them, amphetamine, could affect the functionality of hypothalamic dopamine neurons and thereby alter behavior. As a result, they identified a hypothalamic site for diurnal control of locomotion and a midbrain-independent cellular target of psychostimulants. The results were published in the prestigious journal Nature Communications.

Selected Literature

Korchynska S, Rebernik P, Pende M, Boi L, Alpar A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath TL, Fisone G, Dodt HU, Hokfelt T, Harkany T*, Romanov RA* A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice. Nat Commun 13: 5944 (2022). *Corresponding authors.
Saper, C. B. & Lowell, B. B. The hypothalamus. Curr. Biol. 24, R1111–R1116 (2014).
Romanov, R. A. et al. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nat. Neurosci. 20, 176–188 (2017).
Ben-Jonathan, N. & Hnasko, R. Dopamine as a prolactin (PRL) inhibitor. Endocr. Rev. 22, 724–763 (2001).
Lee, I. T. et al. Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron 85, 1086–1102 (2015).
Romanov RA, Tretiakov EO, et al "Molecular design of hypothalamus development". Nature, 582(7811):246-252 (2020).
Romanov RA, Alpar A, et al A secretagogin locus of the mammalian hypothalamus controls stress hormone release. Embo Journal 34: 36-54, (2015).

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